Treatment of hepatitis B virus-associated glomerulonephritis: a meta-analysis.

Abstract

AIM:

To evaluate the efficacy of antiviral or corticosteroid treatment on hepatitis B virus-associated glomerulonephritis (HBV-GN).

METHODS:

Six and five trials were used respectively to evaluate the efficacy of either antiviral or corticosteroid treatment on HBV-GN. Pediatric patients were pooled separately to assess their response to the above treatment modalities. The primary and secondary outcomes were remission of proteinuria and clearance of Hepatitis B e-antigen (HBeAg), respectively. A fixed or random effect model was established to collect the data.

RESULTS:

The remission rate of proteinuria (RR = 1.69, 95% CI: 1.08-2.65) and the clearance rate of HBeAg (RR = 6.44, 95% CI: 3.11-13.35) were significantly higher in antiviral treatment group than in control group. The proteinuria remission was significantly associated with HBeAg clearance (P = 0.002). However, the difference in proteinuria remission rate was not statistically significant between corticosteroid treatment group and control group (RR = 1.45, 95% CI: 0.68-3.11). Antiviral therapy could significantly promote the HBeAg clearance in pediatric patients, but neither antiviral nor corticosteroid therapy could significantly decrease proteinuria in pediatric patients compared to controls.

CONCLUSION:

Antiviral but not corticosteroid treatment can decrease proteinuria and promote HBeAg clearance in HBV-GN patients.

• Authors: Yu Zhang, Jian-Hua Zhou, Xiao-Ling Yin, Feng-Yu Wang
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 16 Issue 6 Pg. 770-7 (Feb 14 2010) ISSN: 2219-2840 [Electronic] United States
• PMID: 20135728 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenal Cortex Hormones
• Antiviral Agents
• Hepatitis B e Antigens
• Lamivudine
• Interferons

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Antiviral Agents (therapeutic use)
• Glomerulonephritis (drug therapy, virology)
• Hepatitis B (drug therapy)
• Hepatitis B e Antigens (blood)
• Hepatitis B virus
• Humans
• Interferons (therapeutic use)
• Lamivudine (therapeutic use)
• Proteinuria (drug therapy)
• Treatment Outcome