[Afobazole effect on cerebral circulation under hemorrhagic stroke model conditions].

Abstract

Narcotized rats under hemorrhagic stroke model conditions exhibit a significant decrease in the cerebral flow in the region of contralateral cerebral hemisphere symmetric to the zone of lesion. Under these conditions, afobazole produced a significant increase in the local circulation in cerebral cortex, which was violated by hemorrhagic stroke. The cerebrovascular effect of afobazole was not manifested in cases of hemorrhagic stroke on the background of GABA receptor blocking by bicuculline. The obtained results demonstrate that afobazole increases the cerebral blood flow not only under conditions of global transient cerebral ischemia, but on the hemorrhagic stroke model as well, which is probably related to a mediated drug effect on the GABA receptor complex.

• Authors: T S Gan'shina, I N Kurdiumov, A I Turilova, R S Mirzoian, S B Seredenin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2009 Nov-Dec Vol. 72 Issue 6 Pg. 18-21 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 20095394 (Publication Type: English Abstract, Journal Article)

Chemical References

• 2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole
• Benzimidazoles
• GABA Antagonists
• Morpholines
• Receptors, GABA
• Bicuculline

Topics

• Animals
• Benzimidazoles (pharmacology)
• Bicuculline (pharmacology)
• Cerebrovascular Circulation (drug effects)
• Disease Models, Animal
• GABA Antagonists (pharmacology)
• Intracranial Hemorrhages (drug therapy, metabolism)
• Male
• Morpholines (pharmacology)
• Rats
• Receptors, GABA (metabolism)
• Stroke (drug therapy, metabolism)