GABA Receptors (GABA Receptor)

Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.

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Networked: 756 relevant articles (17 outcomes, 86 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Paulose, C S: 6 articles (08/2012 - 10/2010)
2.	Kaufman, Daniel L: 5 articles (10/2020 - 01/2011)
3.	Tian, Jide: 5 articles (10/2020 - 01/2011)
4.	Felipo, Vicente: 4 articles (01/2020 - 12/2013)
5.	Agúndez, José A G: 4 articles (01/2018 - 02/2011)
6.	Alonso-Navarro, Hortensia: 4 articles (01/2018 - 02/2011)
7.	García-Martín, Elena: 4 articles (01/2018 - 02/2011)
8.	Jiménez-Jiménez, Félix Javier: 4 articles (01/2018 - 02/2011)
9.	Zhang, Guang-Yi: 4 articles (09/2012 - 04/2008)
10.	Abramson, R K: 4 articles (05/2006 - 02/2000)

Related Diseases

1.	Seizures (Absence Seizure) 02/19/1993 - "In the present study, we determined that blockade of GABA receptors in SC could also protect against focally evoked limbic motor seizures. " 03/02/1992 - "The purpose of this work was to study the binding parameters of the Na(+)-independent GABA receptors in the brain of a strain of rats presenting spontaneous generalized non-convulsive seizures. " 01/01/2023 - "However, the reduction of membrane KCC2 is associated with the damaged inhibitory ability of the vital GABA receptors, which ultimately leads to the significantly increased susceptibility to epileptic seizures. " 01/01/2021 - "Seizures and ASD may be the result of similar mechanisms, such as abnormalities in GABAergic fibers or GABA receptor function. " 04/01/2018 - "Recurrent neonatal seizures also switch the effect of gamma-aminobutyric acid receptor activation from inhibition to excitation, which may contribute to increased seizure susceptibility. "
2.	Epilepsy (Aura) 12/01/2021 - "This study explores the genetic association between GABA receptor gene polymorphisms and epilepsy in a cohort of the Pakistani population. " 10/01/2022 - "GABRA1, GABRA2, GABRA5, GABRB1, GABRB2, GABRB3, GABRG2 and GABBR2 are genes that encode GABA receptors and are commonly associated with epilepsy. " 12/01/2021 - "Therefore, both the GABA receptor genes may play critical roles in the development of epilepsy in Pakistani patients." 12/01/2021 - "The GABA receptor is an important epilepsy-associated candidate gene, and has always been a focus in etiology and in the treatment of epilepsy. " 01/01/2019 - "The present data point to the importance of GABAergic neurotransmission in seizure-induced cell injury in the amygdala of patients with MTLE and suggest several GABA receptor subunits as potential druggable target structures to control epilepsy and its comorbid disorders, such as anxiety."
3.	Alcoholism (Alcohol Abuse) 11/01/2007 - "GABA receptor systems have long been implicated in alcoholism, and GABAergic drugs have demonstrated efficacy in altering alcohol intake in some rodent models. " 08/18/2011 - "The role of the GABA receptor alpha-2 gene (GABRA2) in human alcohol dependence was determined in a genetic and electrophysiological study. " 11/01/2008 - "Numerous studies showed an association between variants within GABA receptors genes and the risk of alcohol dependence.In" 09/01/2017 - "A SNP variant of rs279871, in the chromosome 4 gene encoding gamma-aminobutyric acid receptor (GABRA2), was selected due to its associations with alcoholism in young adults and with behaviors that increased risk for early drinking. " 08/01/2014 - "GABA Receptors Genes Polymorphisms and Alcohol Dependence: No Evidence of an Association in an Italian Male Population."
4.	Pain (Aches) 12/01/2023 - "Here we highlight recent updates on the involvement of specific GABA receptors and their subtypes in the process of pain sensation. " 12/01/2023 - "Different GABA receptors regulate pain sensation via different signaling pathways. " 01/01/2020 - "Stimulation of GABA receptors in the PAG of PD rats also blunted pain responses. " 09/18/2015 - "These findings reinforce the idea of targeting peripheral GABA receptors for pain relief. " 03/01/2007 - "Since the rACC has a high density of GABA receptors, it is possible that pain processing is influenced by these receptors in the rACC. "
5.	Hypoxia (Hypoxemia) 01/01/2023 - "Briefly, hypoxia caused opposite effects on the gene transcription of the evaluated ionotropic and metabotropic GABA receptors. " 01/01/2021 - "auratus manifest a paroxysmal depolarization shift, a key feature of epileptic discharge.NEW & NOTEWORTHY This work shows that the combination of anoxia and inhibition of GABA receptors induces seizure-like activities in goldfish telencephalic pyramidal and stellate neurons. " 01/01/2021 - "In conclusion, our results indicate that with severe hypoxia and absence of GABA receptor activity, telencephalic neurons of C. " 01/01/2021 - "GABA receptor inhibition and severe hypoxia induce a paroxysmal depolarization shift in goldfish neurons." 01/01/2017 - "Stellate and pyramidal neurons in goldfish telencephalon respond differently to anoxia and GABA receptor inhibition."

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	Proteins (Proteins, Gene)
3.	GABA Agonists (GABA Receptor Agonists)
4.	Morphine (MS Contin)
5.	Picrotoxin
6.	Muscimol
7.	Sodium Channels (Sodium Channel)
8.	Anticonvulsants (Antiepileptic Drugs)
9.	Therapeutic Uses
10.	Phenobarbital (Luminal)

Related Therapies and Procedures

1.	Cell- and Tissue-Based Therapy (Cell Therapy)
2.	Therapeutics
3.	Ligation
4.	Acupuncture Therapy
5.	Electroacupuncture