Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo.

Abstract

Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy.

• Authors: An-Chi Tsai, Shiow-Lin Pan, Cho-Hwa Liao, Jih-Hwa Guh, Shih-Wei Wang, Hui-Lung Sun, Yi-Nan Liu, Chien-Chih Chen, Chien-Chang Shen, Ya-Ling Chang, Che-Ming Teng
• Journal: Cancer letters (Cancer Lett) Vol. 292 Issue 2 Pg. 163-70 (Jun 28 2010) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 20056528 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Benzyl Compounds
• Plant Extracts
• Vascular Endothelial Growth Factor A
• Fibroblast Growth Factor 2
• dendrophenol

Topics

• Animals
• Benzyl Compounds (pharmacology)
• Blotting, Western
• Cell Division (drug effects)
• Cell Line
• Dendrobium (chemistry)
• Fibroblast Growth Factor 2 (drug effects, physiology)
• Humans
• In Vitro Techniques
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Nude
• Neoplasms (blood supply, pathology)
• Neovascularization, Pathologic (prevention & control)
• Plant Extracts (pharmacology)
• Vascular Endothelial Growth Factor A (drug effects, physiology)