The peptide pyroGlu-Gln-Gly-Ser-Asn, isolated from mouse liver, inhibits growth of rat hepatoma cells in vitro.

Abstract

The peptide pyroGlu-Gln-Gly-Ser-Asn, recently isolated from mouse liver, inhibited DNA synthesis and proliferation in vitro of MH1C1 cells, a rat clonal strain derived from a Morris transplantable hepatoma. Both the biological peptide isolated from mouse liver and the synthetic homolog showed bell-shaped dose-response curves. Maximal inhibition (approximately 50%) was observed at two separate dose ranges: one at 10(-7)-10(-10) M, and one at 10(-14)-10(-15) M.

• Authors: J E Paulsen, K Sundby-Hall, L Endresen, H E Rugstad, K L Reichelt, K Elgjo
• Journal: Carcinogenesis (Carcinogenesis) Vol. 12 Issue 2 Pg. 207-10 (Feb 1991) ISSN: 0143-3334 [Print] England
• PMID: 1995186 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oligopeptides
• Peptides
• pyroglutamyl-glutaminyl-glycyl-seryl-asparagine
• DNA
• Pyrrolidonecarboxylic Acid

Topics

• Amino Acid Sequence
• Animals
• Cell Division (drug effects)
• DNA (biosynthesis)
• Dose-Response Relationship, Drug
• Liver (chemistry, cytology, drug effects, metabolism)
• Liver Neoplasms, Experimental (drug therapy, pathology)
• Mice
• Molecular Sequence Data
• Neoplasm Transplantation
• Oligopeptides (pharmacology)
• Peptides (isolation & purification, pharmacology)
• Pyrrolidonecarboxylic Acid (analogs & derivatives)
• Rats
• Time Factors
• Tumor Cells, Cultured