Abstract |
A 39 years old male patient with a history of an unresectable thymoma and synchronous liver metastases was referred tor our position. The patient had been originally treated with systemic chemotherapy followed by imatinib ( Glivec) and sunitinib ( Sutent). Since the therapeutic response was unsatisfactory, a gallium-68 ((68)Ga)-Dotatoc-positron emission tomography (PET) was performed and demonstrated an enhanced SSTR 2 expression in the primary tumor but not in the liver metastases. Three cycles of yttrium-90 ((90)Y)-Dotatoc were then administered. Outcome after treatment was monitored by (18)F-FDG-PET and CT and showed a response only of the primary tumor. Selective internal radiation treatment ( SIRT) with (90)Y microspheres was then applied for the liver metastases. (18)F-FDG uptake showed that metabolism in the liver metastases decreased after SIRT. MRI of the liver demonstrated a decrease in vascularization and a modest decrease in tumor volume. Therefore, surgical resection of the primary thymoma was initiated.
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Authors | Julie Vasamiliette, Peter Hohenberger, Stefan Schoenberg, Steffen Diehl, Dietmar J Dinter, Alexander Marx, Philipp Stroebel, Ludwig G Strauss, Antonia Dimitrakopoulou-Strauss |
Journal | Hellenic journal of nuclear medicine
(Hell J Nucl Med)
2009 Sep-Dec
Vol. 12
Issue 3
Pg. 271-3
ISSN: 1790-5427 [Print] Greece |
PMID | 19936342
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Adult
- Fluorodeoxyglucose F18
- Humans
- Liver Neoplasms
(diagnostic imaging, secondary, therapy)
- Male
- Positron-Emission Tomography
(methods)
- Prognosis
- Radiopharmaceuticals
(therapeutic use)
- Thymoma
(diagnostic imaging, secondary, therapy)
- Thyroid Neoplasms
(diagnostic imaging, therapy)
- Treatment Outcome
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