The use of a cytokine panel to define the long-term risk stratification of heart failure/death in patients presenting with chest pain to the emergency department.

Abstract

OBJECTIVE:

To determine if a cytokine panel could be informative regarding subsequent heart failure(HF)/death.

DESIGN AND METHODS:

In 216 subjects presenting with chest pain to an emergency department in 1996, EDTA plasma (-70 degrees C) was thawed for IL-6, MCP-1, IL-10, VEGF, EGF measurement.

RESULTS:

Subjects with any three cytokines elevated were at higher risk for HF/death compared to those with < or = two cytokines elevated.

DISCUSSION:

A cytokine panel might be useful for risk stratification for HF/death.

• Authors: Peter A Kavsak, Alice M Newman, Dennis T Ko, Andrew R Macrae, Allan S Jaffe
• Journal: Clinical biochemistry (Clin Biochem) Vol. 43 Issue 4-5 Pg. 505-7 (Mar 2010) ISSN: 1873-2933 [Electronic] United States
• PMID: 19913003 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Chemical References

• Cytokines

Topics

• Aged
• Chest Pain (blood)
• Cytokines (blood)
• Death
• Emergency Service, Hospital
• Female
• Heart Failure (blood)
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Risk Factors
• Time Factors