Short communication: Methamphetamine treatment increases in vitro and in vivo HIV replication.

Abstract

To delineate the mechanistic basis for the epidemiological association between methamphetamine use and accelerated progression to AIDS, we evaluated the direct in vitro and in vivo effects of methamphetamine on HIV-1 replication. Methamphetamine administration significantly increased HIV-1 production by both HIV-infected monocytes and CD4 T lymphocytes in vitro. In addition, in vivo methamphetamine treatment increased HIV production and viremia in mice transgenic for a replication-competent HIV provirus and human cyclin T1. Methamphetamine activated transcription of the HIV long terminal repeat (LTR) regulatory region, was associated with nuclear translocation of NF-kappaB. Our results provide further insights into the mechanisms by which methamphetamine accelerates disease course in HIV-infected individuals.

• Authors: Sima Shelly Toussi, Aviva Joseph, Jian Hua Zheng, Monica Dutta, Laura Santambrogio, Harris Goldstein
• Journal: AIDS research and human retroviruses (AIDS Res Hum Retroviruses) Vol. 25 Issue 11 Pg. 1117-21 (Nov 2009) ISSN: 1931-8405 [Electronic] United States
• PMID: 19895343 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Cyclin T
• Methamphetamine

Topics

• Animals
• CD4-Positive T-Lymphocytes (drug effects, virology)
• Cells, Cultured
• Cyclin T (genetics, metabolism)
• HIV Infections (drug therapy, virology)
• HIV Long Terminal Repeat (drug effects, genetics, physiology)
• HIV-1 (drug effects, physiology)
• Humans
• Macrophages (drug effects, virology)
• Methamphetamine (administration & dosage, pharmacology)
• Mice
• Mice, Transgenic
• Viremia (drug therapy, virology)
• Virus Replication (drug effects)