[Two cases of acute myeloid leukemia with t(16;21)(p11;q22) and TLS/FUS-ERG fusion transcripts].

Abstract

Many AML-associated chromosomal abnormalities, such as t(8;21), t(15;17), inv(16), t(9;11), t(9;22) and t(6;9) are well known. The chromosomal aberration of t(16;21)(p11;q22) in AML is rare and it is known to be associated with poor prognosis, young age (median age, 22 yr), and involvement of various subtypes of the French-American-British classification. We report here 2 AML patients with t(16;21)(p11;q22), proved by conventional cytogenetics and/or reverse transcription (RT)-PCR. Erythrophagocytosis by leukemic blasts was observed in both of the cases. One patient was a 24 yr-old male with acute myelomonocytic leukemia. His karyotype was 46,XY,t(16;21)(p11;q22),del(18)(p11.2) and RT-PCR revealed the TLS/FUS-ERG fusion transcripts. Although he received allogeneic peripheral blood stem cell transplantation after the first remission, he died 9 months after the initial diagnosis due to relapse of the disease and graft-versus-host disease. The other patient was a 72 yr-old male with acute myeloid leukemia without maturation. His karyotype was 45,XY,-16,add(21)(q22) and the presence of t(16;21)(p11;q22) was detected by RT-PCR. He was transferred to another hospital with no more follow-up. We suggest that the presence of t(16;21)(p11;q22) and/or TLS/FUS-ERG fusion transcripts has to be considered in cases of AML with erythrophagocytosis.

• Authors: Woong Rin Chang, Il Joong Park, Hyun Woo Lee, Joon Seong Park, Hugh Chul Kim, Hyon Joo Kim, Jae Ho Han, Sung Ran Cho
• Journal: The Korean journal of laboratory medicine (Korean J Lab Med) Vol. 29 Issue 5 Pg. 390-5 (Oct 2009) ISSN: 1598-6535 [Print] Korea (South)
• PMID: 19893346 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Oncogene Proteins, Fusion
• RNA-Binding Protein FUS
• TLS-ERG fusion protein, human

Topics

• Aged
• Chromosomes, Human, Pair 16 (genetics)
• Chromosomes, Human, Pair 22 (genetics)
• Graft vs Host Disease (diagnosis)
• Humans
• Karyotyping
• Leukemia, Myeloid, Acute (diagnosis, genetics)
• Male
• Oncogene Proteins, Fusion (genetics)
• RNA-Binding Protein FUS (genetics)
• Reverse Transcriptase Polymerase Chain Reaction
• Translocation, Genetic
• Young Adult