Abstract | BACKGROUND: METHODS: Prospectively collected clinical data on 83 consecutive patients with DMPM undergoing surgical cytoreduction and closed-abdomen HIPEC with cisplatin and doxorubicin were reviewed. Clinically suspicious lymph nodes were submitted to pathological examination. The impact of nodal involvement on survival was assessed by multivariate analysis; 14 clinicopathological control variables were tested. RESULTS: For the overall series, median follow-up was 52 months (range 1-126 months) and 5-year overall survival (OS) was 49.5%. Lymph nodes were submitted to pathological examination in 38 patients, being positive in 11 and negative in 27. Lymph nodes were not clinically suspicious and not sampled in 45 patients. Iliac (n = 7) and paracolic (n = 2) nodes were the most commonly involved nodes. OS was 18.0% for patients with pathologically positive nodes and 82.5% for those with pathologically negative nodes (P = 0.0024). On multivariate analysis, pathologically negative (versus positive/not assessed) nodes [hazard ratio (HR) = 2.81; 95% confidence interval (CI) = 1.12-7.05; P = 0.027], epithelial subtype (HR = 2.93; CI = 1.24-6.95; P = 0.015), mitotic count <or=5/50 high-power microscopic fields (HPF) (HR = 5.34; CI = 1.96-14.54; P = 0.001), and completeness of cytoreduction (HR = 2.06; CI = 1.19-3.56; P = 0.001) correlated with increased OS. Positive nodes (versus negative/not assessed) did not significantly correlate with survival. CONCLUSION: Pathologically negative nodes (as compared with pathological positive and not assessed), along with pathological and biological features, independently correlated with increased survival following comprehensive treatment. This suggests the need for careful node sampling when performing surgical cytoreduction for DMPM patients.
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Authors | Dario Baratti, Shigeki Kusamura, Antonello Domenico Cabras, Barbara Laterza, Maria Rosaria Balestra, Marcello Deraco |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 17
Issue 1
Pg. 45-53
(Jan 2010)
ISSN: 1534-4681 [Electronic] United States |
PMID | 19856030
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chemotherapy, Cancer, Regional Perfusion
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Doxorubicin
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Hyperthermia, Induced
- Lymph Nodes
(pathology, surgery)
- Lymphatic Metastasis
- Male
- Mesothelioma
(drug therapy, secondary, surgery)
- Middle Aged
- Peritoneal Neoplasms
(drug therapy, pathology, surgery)
- Prognosis
- Prospective Studies
- Survival Rate
- Young Adult
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