Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia.

Abstract

OBJECTIVE:

To examine the potential value of maternal serum concentration of placental protein 13 (PP13) at 11-13 weeks' gestation in screening for preeclampsia (PE).

METHODS:

Serum PP13, PAPP-A and uterine artery pulsatility index (PI) were determined in a case-control study of 208 cases that developed PE including 48 that required delivery before 34 weeks (early-PE) and 416 unaffected controls.

RESULTS:

Serum PP13 levels, expressed as multiples of the median (MoM) in the unaffected group, were significantly reduced in early-PE (0.83 MoM) but not in late-PE (0.96 MoM). In both early- and late-PE serum PAPP-A (0.55 and 0.84 MoM) was reduced and uterine artery PI (1.61 and 1.25 MoM) was increased. In PE pregnancies there was a significant association between serum PP13 and both uterine artery PI and serum PAPP-A (p < 0.0001 for both). Logistic regression analysis demonstrated that serum PP13 did not improve significantly the prediction of early-PE provided by a combination of maternal factors, uterine artery PI and PAPP-A.

CONCLUSION:

PP13 is implicated in the pathogenesis of impaired placentation and subsequent development of early-PE but measurement of this placental product is unlikely to be useful in screening for the disease at 11-13 weeks.

• Authors: Ranjit Akolekar, Argyro Syngelaki, Jarek Beta, Rafal Kocylowski, Kypros H Nicolaides
• Journal: Prenatal diagnosis (Prenat Diagn) Vol. 29 Issue 12 Pg. 1103-8 (Dec 2009) ISSN: 1097-0223 [Electronic] England
• PMID: 19777530 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Galectins
• LGALS13 protein, human
• Pregnancy Proteins
• Pregnancy-Associated Plasma Protein-A

Topics

• Age of Onset
• Case-Control Studies
• False Positive Reactions
• Female
• Galectins (blood)
• Gestational Age
• Humans
• Mothers
• Placentation (physiology)
• Pre-Eclampsia (blood, diagnosis, epidemiology, etiology)
• Pregnancy
• Pregnancy Proteins (blood)
• Pregnancy Trimester, First (blood)
• Pregnancy-Associated Plasma Protein-A (analysis)
• Prenatal Diagnosis
• Risk Factors
• Time Factors