[Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats].

Abstract

OBJECTIVE:

To observe the effect of 3'-methoxy puerarin on cerebral infarction volume and free radical change of focal cerebral ischemia-reperfusion injury in rats and discuss the protective effect of 3'-methoxy puerarin on the cerebral ischemic/ reperfusion injury.

METHOD:

The thread method was used to induce middle cerebral artery embolization, to establish the focal cerebral ischemia-reperfusion model. Rats were divided into five groups: the sham and model group, the two-dose group (5, 10 mg x kg(-1) x d(-1)) of 3'-methoxy puerarin and nimodipine group (5 mg x kg(-1) x d(-1)). The behavior changes and volume of cerebral infarction were observed, and the leves of SOD and the content of MDA were measured.

RESULT:

3'-methoxy puerarin could significantly improve the symptoms of neurological deficit and reduce the infarct volume, and increased SOD activity and reduced the content of MDA of cortex in cerebral ischemia-reperfusion injury rat, the action of 10 mg x kg(-1) of 3'-methoxy puerarin is more remarkable.

CONCLUSION:

3'-methoxy puerarin has protective effect on focal cerebral ischemia-reperfusion injury in rat.

• Authors: Jin Han, Haitong Wan, Lijun Ge, Zhenhong Zhu, Ying Guo, Yuyan Zhang, Jinhui Li
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 34 Issue 11 Pg. 1422-5 (Jun 2009) ISSN: 1001-5302 [Print] China
• PMID: 19771877 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Isoflavones
• puerarin

Topics

• Animals
• Brain Ischemia (drug therapy, prevention & control)
• Disease Models, Animal
• Female
• Humans
• Isoflavones (pharmacology)
• Male
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Reperfusion Injury (drug therapy, prevention & control)