Abstract |
Psychological stress can modulate host defense against invading pathogens. In this study, we investigated the effect of dietary oils on social isolation stress-induced modulation of host resistance to Paracoccidioides brasiliensis. In olive oil-fed mice, 3 weeks of isolation stress resulted in temporarily delayed clearance of this fungus in the liver compared with group-housed mice. By contrast, in soybean oil-fed mice, isolation stress had no significant effect on antifungal activity. The olive oil-fed mice showed greater liver interferon (IFN)-gamma and interleukin (IL)-6 production in response to infection as compared with the soybean oil-fed mice. In the olive oil-fed mice, isolation stress led to greater infection-induced IFN-gamma production in the liver compared with the group-housed animals. These results indicate that the modulatory effects of psychological stress on host resistance to P. brasiliensis can vary depending on dietary fatty acid composition.
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Authors | Motoko Oarada, Miki Igarashi, Tsuyoshi Tsuzuki, Nobuyuki Kurita, Tohru Gonoi, Takeshi Nikawa, Katsuya Hirasaka, Teruo Miyazawa, Kiyotaka Nakagawa, Katsuhiko Kamei |
Journal | Bioscience, biotechnology, and biochemistry
(Biosci Biotechnol Biochem)
Vol. 73
Issue 9
Pg. 1994-8
(Sep 2009)
ISSN: 1347-6947 [Electronic] England |
PMID | 19734677
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Fats, Unsaturated
- Interleukin-6
- Interferon-gamma
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Topics |
- Animals
- Dietary Fats, Unsaturated
(pharmacology)
- Female
- Interferon-gamma
(biosynthesis)
- Interleukin-6
(biosynthesis)
- Liver
(drug effects, metabolism)
- Mice
- Mice, Inbred BALB C
- Mycoses
(immunology)
- Organ Size
(drug effects)
- Social Isolation
- Spleen
(drug effects)
- Stress, Psychological
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