Alarmins link neutrophils and dendritic cells.

Abstract

Neutrophils are the first major population of leukocyte to infiltrate infected or injured tissues and are crucial for initiating host innate defense and adaptive immunity. Although the contribution of neutrophils to innate immune defense is mediated predominantly by phagocytosis and killing of microorganisms, neutrophils also participate in the induction of adaptive immune responses. At sites of infection and/or injury, neutrophils release numerous mediators upon degranulation or death, among these are alarmins which have a characteristic dual capacity to mobilize and activate antigen-presenting cells. We describe here how alarmins released by neutrophil degranulation and/or death can link neutrophils to dendritic cells by promoting their recruitment and activation, resulting in the augmentation of innate and adaptive immune responses.

• Authors: De Yang, Gonzalo de la Rosa, Poonam Tewary, Joost J Oppenheim
• Journal: Trends in immunology (Trends Immunol) Vol. 30 Issue 11 Pg. 531-7 (Nov 2009) ISSN: 1471-4981 [Electronic] England
• PMID: 19699678 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Review)

Chemical References

• Antimicrobial Cationic Peptides
• Cytokines
• Defensins
• HMGB1 Protein
• Lactoferrin
• Cathelicidins

Topics

• Adaptive Immunity
• Animals
• Antimicrobial Cationic Peptides (metabolism)
• Cell Communication (immunology)
• Cell Degranulation
• Cytokines (metabolism)
• Defensins (metabolism)
• Dendritic Cells (immunology, metabolism)
• HMGB1 Protein (metabolism)
• Humans
• Immunity, Innate
• Lactoferrin (metabolism)
• Neutrophils (immunology, metabolism)
• Cathelicidins