[Nutrition and bone health. Roles of vitamin C and vitamin B as regulators of bone mass and quality].

Abstract

Vitamin C and a vitamin B are essential nutrients to maintain bone density and bone quality. Recent literature clearly shows that vitamin C and B affect bone quality determinant "collagen cross-link formation" . Mildly elevated plasma homocysteine levels induced by vitamin B insufficiency and methylenetetrahydrofolate reductase (MTHFR) deteriorate normal collagen cross-link formation (Saito M, Osteoporos Int 2009 May 30. [Epub ahead of print] , Shiraki M and Saito M, J Bone Miner Metab [6] 2008) . In this review, we describe the effects of vitamin C and vitamin B insufficiency and hyperhomocysteinemia on bone quality in terms of collagen cross-link formation in bone that have been reported in the literature.

• Authors: Mitsuru Saito
• Journal: Clinical calcium (Clin Calcium) Vol. 19 Issue 8 Pg. 1192-9 (Aug 2009) ISSN: 0917-5857 [Print] Japan
• PMID: 19638704 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Homocysteine
• Vitamin B Complex
• Collagen
• Ascorbic Acid

Topics

• Ascorbic Acid (physiology)
• Ascorbic Acid Deficiency (physiopathology)
• Bone Density
• Collagen (metabolism)
• Homocysteine (metabolism)
• Humans
• Hyperhomocysteinemia (physiopathology)
• Vitamin B Complex (physiology)
• Vitamin B Deficiency (physiopathology)