[Antiarrhythmic activity of adrenergic blockaders with different mechanisms of action].

Abstract

Experiments have demonstrated that Alfeprol arrests atrial fibrillation in dogs induced by electric stimulation of the heart, and atrial fibrillation in cats modelled by Akonitine application; it suppresses ventricular tachycardia in dogs occurring following an occlusion of the branches of coronary arteries, and in cats when induced by strophantin intoxication; it prevents fatal ventricular fibrillation in rats poisoned by calcium chloride. The antiarrhythmic effect of Anaprille was not so persistent and manifested itself only in cases of some particular rhythm disorders. Ornid displayed no antiarrhythmic activity. The blocking of adrenergic innervation of the heart by means of beta-adrenergic blockers (Alfeprol, Anaprilline) and sympatholytic (Reserpine, Ornid) considerably increased the animals tolerance of the toxic effect of strophantin, decreasing its arrhythmogenic effect in particular. The mechanisms of the antiarrhythmic effect of antiadrenergic agents are discussed along with the possibilities of their employment for the correction of cardiac sensitivity of glycosides.

• Authors: E I Gendenshteĭn, Ia V Kostin, N D Volkova
• Journal: Kardiologiia (Kardiologiia) Vol. 17 Issue 4 Pg. 116-20 (Apr 1977) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Protivoaritmicheskaia aktivnost' antiadrenergicheskikh sredstv s raznym mekhanizmom deĭstviia.
• PMID: 196133 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Bretylium Compounds
• Receptors, Adrenergic, beta
• Bretylium Tosylate
• Alprenolol
• Propranolol

Topics

• Alprenolol (analogs & derivatives, pharmacology, therapeutic use)
• Animals
• Anti-Arrhythmia Agents (pharmacology, therapeutic use)
• Atrial Fibrillation (drug therapy)
• Bretylium Compounds (therapeutic use)
• Bretylium Tosylate (pharmacology, therapeutic use)
• Cats
• Dogs
• Drug Evaluation
• Heart (innervation)
• Propranolol (pharmacology, therapeutic use)
• Rats
• Receptors, Adrenergic, beta (drug effects)