Abstract | BACKGROUND: METHODS: On Day 0, a surgical plantar incision was performed in one hindpaw of rats treated or untreated with fentanyl (4 x 100 microg/kg, one injection every 15 min). Nefopam (10 mg/kg) or saline was subcutaneously injected 30 min before injury. Three weeks later, once pain measures had returned to basal values, a subsequent nociceptive stimulus, specifically intraplantar carrageenan injection, was performed to evaluate pain sensitivity in incision- and fentanyl-experienced rats. Pain was measured by the paw-pressure vocalization test and the weight bearing test. RESULTS: CONCLUSIONS:
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Authors | Emilie Laboureyras, Jeremy Chateauraynaud, Philippe Richebé, Guy Simonnet |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 109
Issue 2
Pg. 623-31
(Aug 2009)
ISSN: 1526-7598 [Electronic] United States |
PMID | 19608840
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Non-Narcotic
- Analgesics, Opioid
- Nefopam
- Carrageenan
- Fentanyl
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Topics |
- Analgesics, Non-Narcotic
(therapeutic use)
- Analgesics, Opioid
- Animals
- Carrageenan
- Chronic Disease
- Fentanyl
- Hyperalgesia
(chemically induced, drug therapy)
- Male
- Nefopam
(therapeutic use)
- Pain
(chemically induced, prevention & control)
- Pain Measurement
(drug effects)
- Pain, Postoperative
(etiology, prevention & control)
- Rats
- Rats, Sprague-Dawley
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