Abstract |
The present study investigated the protein expression level of CXCL12 in colorectal cancer and aimed to elucidate its association with prognosis. CXCL12 positivity in 50% or more of tumor cells was defined as high expression and that in less than 50% of the tumor cells as low expression. CXCL12+ tumor budding at the invasive front was divided into 2 grades: high with 10 or more budding foci per x200 field of view and low grade with fewer than 10 budding foci. Patients with high expression (72.7%) and high grade CXCL12+ tumor budding (43.0%) had significantly shorter survival than patients with low expression (P = .014) and low grade (P = .003), respectively. Patients with a combination of high expression and high grade had the worst outcome (P < .001). Our study demonstrated that CXCL12 expression in colorectal cancer cells and at sites of budding were significant prognostic factors. Furthermore, together with lymph node metastasis, a combination of both expression patterns was a more powerful independent prognostic factor.
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Authors | Yuri Akishima-Fukasawa, Yukihiro Nakanishi, Yoshinori Ino, Yoshihiro Moriya, Yae Kanai, Setsuo Hirohashi |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 132
Issue 2
Pg. 202-10; quiz 307
(Aug 2009)
ISSN: 1943-7722 [Electronic] England |
PMID | 19605814
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Chemokine CXCL12
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Chemokine CXCL12
(biosynthesis)
- Colorectal Neoplasms
(metabolism, mortality, pathology)
- Female
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
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