Abstract |
Young mink kits (n=8) were vaccinated with DNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodies were induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN-gamma producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.
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Authors | Trine Hammer Jensen, Line Nielsen, Bent Aasted, Merete Blixenkrone-Møller |
Journal | Vaccine
(Vaccine)
Vol. 27
Issue 38
Pg. 5178-83
(Aug 20 2009)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 19596418
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Hemagglutinins, Viral
- Vaccines, DNA
- Viral Vaccines
- Interferon-gamma
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Topics |
- Animals
- Antibodies, Viral
(blood, immunology)
- Chlorocebus aethiops
- Distemper
(immunology, prevention & control)
- Distemper Virus, Canine
(immunology)
- Hemagglutinins, Viral
(immunology)
- Interferon-gamma
(immunology)
- Mink
(immunology, virology)
- Neutralization Tests
- Plasmids
- Vaccines, DNA
(immunology)
- Vero Cells
- Viral Vaccines
(immunology)
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