Successful management of presumed Candida endogenous endophthalmitis with oral voriconazole.

Abstract

Endogenous fungal endophthalmitis is most commonly caused by Candida species and usually occurs in patients with chronic diseases such as diabetes mellitus and renal insufficiency. Voriconazole, a broad-spectrum triazole antifungal agent, attains therapeutically significant concentrations in the vitreous cavity after systemic administration. We report, the successful management of presumed endogenous Candida endophthalmitis in a patient with multiple diseases and unstable systemic status with oral voriconazole. Though fungal endophthalmitis has been successfully treated with a combination of intravenous and intravitreal voriconazole, to the best of our knowledge this is the first report in ophthalmic literature (Medline Search) on the treatment of fungal endophthalmitis with only the oral route of administration of voriconazole.

• Authors: Raju Biju, Daniel Sushil, Nainan K Georgy
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) 2009 Jul-Aug Vol. 57 Issue 4 Pg. 306-8 ISSN: 1998-3689 [Electronic] India
• PMID: 19574701 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Pyrimidines
• Triazoles
• Voriconazole

Topics

• Administration, Oral
• Aged
• Antifungal Agents (administration & dosage)
• Candidiasis (drug therapy)
• Endophthalmitis (metabolism, microbiology, pathology)
• Exudates and Transudates (drug effects, metabolism)
• Humans
• Male
• Pyrimidines (administration & dosage)
• Treatment Outcome
• Triazoles (administration & dosage)
• Vitreous Body (drug effects, metabolism, pathology)
• Voriconazole