Abstract | BACKGROUND: OBJECTIVES: The purposes of this study were to describe amlodipine poisoning in children and to determine whether a dose-response relationship could be detected in this population using standardized call data from United States (US) poison centers. PATIENTS AND METHODS: 1251 amlodipine-only ingestions in children < 6 years of age were reviewed. Cases with doses coded as "Exact" or "Estimated" and with dose, age, and medical outcome were analyzed (n = 678). Ingestions reported as a "taste or lick" (n = 53) were included as a dose of 1/10 of the dosage form involved. A clinically important response was defined as bradycardia, hypotension, dysrhythmia, conduction disturbance, or hyperglycemia. The risk of such responses was examined over four dosage intervals (< 2.5 mg, 2.5-5 mg, 5.1-10 mg, and > 10 mg). RESULTS: The median estimated dose ingested was 5 mg (range 0.25-200 mg). Clinically important responses developed in 27 patients (3.98%), and the prevalence of such response significantly increased from 0% for the lowest to 11.1% for the highest dose interval (p = 0.001). The smallest dose to produce a clinically important response was 2.5 mg (0.15 mg/kg). Children who ingested > 10 mg were 4.4 times more likely to develop clinically important responses than those ingesting < or = 5 mg. CONCLUSION:
Hypotension may occur in children with amlodipine doses as low as 2.5 mg. The National Poison Data System might provide useful insights regarding dose-response.
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Authors | Blaine E Benson, Daniel A Spyker, William G Troutman, William A Watson, Ludmila N Bakhireva |
Journal | The Journal of emergency medicine
(J Emerg Med)
Vol. 39
Issue 2
Pg. 186-93
(Aug 2010)
ISSN: 0736-4679 [Print] United States |
PMID | 19535212
(Publication Type: Journal Article)
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Copyright | Copyright 2010 Elsevier Inc. All rights reserved. |
Chemical References |
- Calcium Channel Blockers
- Amlodipine
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Topics |
- Amlodipine
(poisoning)
- Calcium Channel Blockers
(poisoning)
- Child, Preschool
- Databases, Factual
- Dose-Response Relationship, Drug
- Humans
- Hypotension
(chemically induced)
- Infant
- Poison Control Centers
- Vomiting
(chemically induced)
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