Abstract | BACKGROUND:
Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) could ameliorate neurological deficits after stroke in the rodent. OBJECTIVE: The purpose of this study was to investigate the potential mechanisms underlying the neuroprotective effects of implanted BMSCs. METHODS: RESULTS: Significant improvement of neurological deficits was found in BMSC-treated rats compared with control animals at 14 and 28 days after MCAo (p<0.05). Histological evaluation showed that BMSCs treatment significantly promoted neuronal survival and proliferation in the ischemic boundary area. The expression of VEGF was predominantly increased in the ischemic hemisphere of BMSC-treated rats compared with the other groups. On the other hand, transduction of VEGF RNAi lentivirus partially attenuated the above described beneficial effects of systemically administered BMSCs. CONCLUSION: Our data suggest that intravenously administrated BMSCs facilitate neurological function, reduce neuronal apoptosis and promote neuronal proliferation through the release of VEGF.
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Authors | Yu Bin Deng, Wei Biao Ye, Zhen Zhen Hu, Ying Yan, Ye Wang, Bekomson Francis Takon, Guang-Qian Zhou, Yan Fang Zhou |
Journal | Neurological research
(Neurol Res)
Vol. 32
Issue 2
Pg. 148-56
(Mar 2010)
ISSN: 1743-1328 [Electronic] England |
PMID | 19473555
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apoptosis Regulatory Proteins
- Vascular Endothelial Growth Factor A
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Topics |
- Animals
- Apoptosis
(physiology)
- Apoptosis Regulatory Proteins
(metabolism)
- Bone Marrow Cells
(metabolism)
- Cell Proliferation
- Infusions, Intravenous
- Male
- Mesenchymal Stem Cell Transplantation
(methods)
- Neurons
(metabolism, pathology)
- Rats
- Rats, Sprague-Dawley
- Stroke
(metabolism, pathology, surgery)
- Vascular Endothelial Growth Factor A
(metabolism)
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