[Voluntary poisoning by Cortinarius orellanus: usefulness of an original early treatment after determination of orellanine in the biological fluids and tissues].

Abstract

Cortinarius poisoning is generally caused by orellanine, a hydroxy bipyridine N, N-dioxide. This intoxication is characterized by acute nephritis which can lead to death without treatment. We reported a highly sensitive and simple fluorimetric technique to analyse orellanine by thin-layer chromatography on the basis of its characteristic photodecomposition into orelline. Using this procedure, we detected and assayed orellanine for the first time in plasma and renal biopsies of a woman who had deliberately ingested two fruit-bodies of Cortinarius orellanus. An early original treatment was carried out based on hemodialysis, combination plasmapheresis-hemoperfusion, and amino acids and diltiazem administration. These results indicate that it is now possible to make a precise diagnosis of orellanine poisoning.

• Authors: N Delpech, S Rapior, P Donnadieu, A P Cozette, J P Ortiz, G Huchard
• Journal: Nephrologie (Nephrologie) Vol. 12 Issue 2 Pg. 63-6 ( 1991) ISSN: 0250-4960 [Print] Switzerland
• Vernacular Title: Intoxication volontaire par Cortinarius orellanus: intérêt d'un traitement précoce original après dosage de l'orellanine dans les milieux biologiques et tissulaires.
• PMID: 1944757 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amino Acids
• Mycotoxins
• orellanine
• 2,2'-Dipyridyl
• Furosemide
• Diltiazem
• Ascorbic Acid
• Dopamine

Topics

• 2,2'-Dipyridyl (analogs & derivatives, analysis, radiation effects)
• Acute Disease
• Acute Kidney Injury (blood, chemically induced, diagnosis, therapy)
• Adult
• Agaricales
• Amino Acids (therapeutic use)
• Ascorbic Acid (therapeutic use)
• Biopsy
• Chromatography, Thin Layer
• Combined Modality Therapy
• Diltiazem (therapeutic use)
• Dopamine (therapeutic use)
• Female
• Fluorometry
• Furosemide (therapeutic use)
• Hemoperfusion
• Humans
• Kidney (chemistry, pathology)
• Mushroom Poisoning (blood, complications, therapy)
• Mycotoxins (analysis, radiation effects)
• Photochemistry
• Plasmapheresis
• Renal Dialysis