[Antidepressant action of emoxipin and mexidol in mice with alloxan diabetes].

Abstract

The development of alloxan diabetes in mice is accompanied by prolonged desperate behavior (analogous to human depression) and decreased activity of animals in the open field test. Course administration of emoxypin and mexidol in doses corresponding to the human therapeutic range renders the antidepressant action manifested by reduced desperate behavior and increased activity in the open field. The antidepressant effect of emoxypin and mexidol is accompanied by a decrease in the blood glucose level after 14 days of administration. Emoxypin, in contrast to mexidol, provokes transient deterioration of diabetic hyperglycemia after 7 days of administration. Mexidol is characterized by an optimal combination of antidepressant action and favorable impact on carbohydrate metabolism that makes this 3-oxypyridine derivative a promising substance for the treatment of depression in diabetic patients.

• Authors: I A Volchegorskiĭ, L M Rassokhina, I Iu Miroshnichenko
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2009 Mar-Apr Vol. 72 Issue 2 Pg. 11-5 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 19441720 (Publication Type: Journal Article)

Chemical References

• 3-oxypyridine
• Antidepressive Agents
• Blood Glucose
• Picolines
• Psychotropic Drugs
• Pyridines
• emoxypine succinate
• 6-methyl-2-ethyl-3-hydroxypyridine

Topics

• Animals
• Antidepressive Agents (administration & dosage, adverse effects, therapeutic use)
• Behavior, Animal (drug effects, physiology)
• Blood Glucose (analysis)
• Depression (complications, drug therapy)
• Diabetes Mellitus, Experimental (chemically induced, complications, drug therapy)
• Female
• Male
• Mice
• Picolines (administration & dosage, adverse effects, therapeutic use)
• Psychotropic Drugs (administration & dosage, adverse effects, therapeutic use)
• Pyridines (administration & dosage, adverse effects, therapeutic use)