Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system.

Abstract

We studied the effect of fluoroquinolones (FQs) on carrageenan-induced edema in the rat footpad. Ciprofloxacin, gatifloxacin, sparfloxacin, norfloxacin, and enoxacin (s.c., 100 mg/kg), which have piperazinyl and/or cyclopropyl groups, inhibited carrageenan-induced edema, whereas levofloxacin, tosufloxacin, and pazufloxacin did not. The reduction of edema by ciprofloxacin, sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological responses through enhancing the glucocorticoid-glucocorticoid receptor system.

• Authors: Hiromi Ogino, Kaori Yamada, Mizuki Yuhara, Saori Tsuchida, Kayoko Maezawa, Junko Kizu, Seiji Hori
• Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 15 Issue 2 Pg. 113-7 (Apr 2009) ISSN: 1341-321X [Print] Netherlands
• PMID: 19396522 (Publication Type: Journal Article)

Chemical References

• Fluoroquinolones
• Receptors, Glucocorticoid
• Mifepristone
• Carrageenan

Topics

• Analysis of Variance
• Animals
• Carrageenan
• Dose-Response Relationship, Drug
• Edema (chemically induced, drug therapy, metabolism)
• Fluoroquinolones (administration & dosage, pharmacology)
• Foot
• Male
• Mifepristone (pharmacology)
• Rats
• Rats, Wistar
• Receptors, Glucocorticoid (metabolism)
• Structure-Activity Relationship