Prospective risk-adjusted [18F]Fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer.

Abstract

PURPOSE:

[(18)F]Fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) imaging may improve assessment of radiation response in patients with head and neck cancer, but it is not yet known for which patients this is most useful. We conducted a prospective trial to identify patient populations likely to benefit from the addition of functional imaging to the assessment of radiotherapy response.

PATIENTS AND METHODS:

Ninety-eight patients with locally advanced cancer of the oropharynx, larynx, or hypopharynx were prospectively enrolled and treated with primary radiotherapy, with or without chemotherapy. Patients underwent FDG-PET/CT and contrast-enhanced CT imaging 8 weeks after completion of treatment. Functional and anatomic imaging response was correlated with clinical and pathologic response. Imaging accuracy was then compared between imaging modalities.

RESULTS:

Although postradiation maximum standard uptake values were significantly higher in nonresponders compared with responders, the positive and negative predictive values of FDG-PET/CT scanning were similar to those for CT alone in the unselected study population. Subset analyses revealed that FDG-PET/CT outperformed CT alone in response assessment for patients at high risk for treatment failure (those with human papillomavirus [HPV] -negative disease, nonoropharyngeal primaries, or history of tobacco use). No benefit to FDG-PET/CT was seen for low-risk patients lacking these features.

CONCLUSION:

These data do not support the broad application of FDG-PET/CT for radiation response assessment in unselected head and neck cancer patients. However, FDG-PET/CT may be the imaging modality of choice for patients with highest risk disease, particularly those with HPV-negative tumors. Optimal timing of FDG-PET/CT imaging after radiotherapy merits further investigation.

• Authors: Benjamin J Moeller, Vishal Rana, Blake A Cannon, Michelle D Williams, Erich M Sturgis, Lawrence E Ginsberg, Homer A Macapinlac, J Jack Lee, K Kian Ang, K S Clifford Chao, Gregory M Chronowski, Steven J Frank, William H Morrison, David I Rosenthal, Randal S Weber, Adam S Garden, Scott M Lippman, David L Schwartz
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 27 Issue 15 Pg. 2509-15 (May 20 2009) ISSN: 1527-7755 [Electronic] United States
• PMID: 19332725 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Carcinoma, Squamous Cell (diagnostic imaging, pathology, radiotherapy)
• Fluorodeoxyglucose F18
• Head and Neck Neoplasms (diagnostic imaging, pathology, radiotherapy)
• Humans
• Positron-Emission Tomography (methods)
• Predictive Value of Tests
• ROC Curve
• Radiopharmaceuticals
• Tomography, X-Ray Computed (methods)