Association of early experience with neurodegeneration in aged primates.

Abstract

Environment influences brain development, neurogenesis and, possibly, vulnerability to neurodegenerative disease. We retrospectively examined the brains of aged rhesus monkeys reared during early life in either small cages or larger, "standard-sized" cages; all monkeys were subsequently maintained in standard-sized cages during adulthood. Aged monkeys reared in smaller cages exhibited significantly greater β-amyloid plaque deposition in the neocortex and a significant reduction in synaptophysin immunolabeling in cortical regions compared to aged monkeys reared in standard-sized cages (p<0.001 and p<0.05, respectively). These findings suggest that early environment may influence brain structure and vulnerability to neurodegenerative changes in late life.

• Authors: David A Merrill, Eliezer Masliah, Jeffery A Roberts, Heather McKay, Jeffery H Kordower, Elliott J Mufson, Mark H Tuszynski
• Journal: Neurobiology of aging (Neurobiol Aging) Vol. 32 Issue 1 Pg. 151-6 (Jan 2011) ISSN: 1558-1497 [Electronic] United States
• PMID: 19321231 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2008 Elsevier Inc. All rights reserved.

Chemical References

• Synaptophysin
• Oleanolic Acid
• beta-amyrin

Topics

• Aging
• Animals
• Disease Models, Animal
• Environment
• Macaca mulatta
• Neocortex (metabolism, pathology)
• Neurodegenerative Diseases (etiology, metabolism, pathology)
• Oleanolic Acid (analogs & derivatives, metabolism)
• Synaptophysin (metabolism)