Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.

Abstract

Since attention has been paid to the use of multiwalled carbon nanotubes (MWCNTs) as biomaterials in contact with bone, it is critical to understand the reaction of bone cells to MWCNTs. We show that MWCNTs inhibit osteoclastic bone resorption in vivo and that MWCNTs inhibit osteoclastic differentiation and suppressed a transcription factor essential for osteoclastogenesis in vitro. These results suggest that MWCNTs have beneficial effects on bones when they are used as biomaterials.

• Authors: Nobuyo Narita, Yasuhiro Kobayashi, Hiroaki Nakamura, Kazuhiro Maeda, Akihiro Ishihara, Toshihide Mizoguchi, Yuki Usui, Kaoru Aoki, Masayuki Simizu, Hiroyuki Kato, Hidehiro Ozawa, Nobuyuki Udagawa, Morinobu Endo, Naoyuki Takahashi, Naoto Saito
• Journal: Nano letters (Nano Lett) Vol. 9 Issue 4 Pg. 1406-13 (Apr 2009) ISSN: 1530-6992 [Electronic] United States
• PMID: 19284728 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biocompatible Materials
• Nanotubes, Carbon

Topics

• Biocompatible Materials
• Bone Resorption
• Cell Differentiation
• Nanotubes, Carbon
• Osteoclasts (cytology)