Blockade of ICAM-1: a novel way of vasculitis treatment.

Abstract

Vasculitis is becoming more common worldwide, but there is no effective therapeutic method towards this series of disease till now. Intercellular adhesion molecule (ICAM)-1 is one of an important cell adhesion molecules (CAMs) family glycoprotein that plays pivotal role in inflammation process and participates in vasculitis. Blockade of ICAM-1 has been witnessed with its satisfactory effect on inflammatory disease treatment. Therefore, this method may be considered as a novel way towards treatment of vasculitis.

• Authors: Youhua Xu, Shengnan Li
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 381 Issue 4 Pg. 459-61 (Apr 17 2009) ISSN: 1090-2104 [Electronic] United States
• PMID: 19249285 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Intercellular Adhesion Molecule-1

Topics

• Cell Adhesion
• Cell Movement
• Humans
• Intercellular Adhesion Molecule-1 (metabolism)
• Vasculitis (drug therapy, metabolism, pathology)