Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer.

Abstract

BACKGROUND:

p53AIP1 is a potential mediator of apoptosis depending on p53, which is mutated in many kinds of carcinoma. High survivin expression in non-small cell lung cancer is related with poor prognosis. To investigate the role of these genes in non-small cell lung cancer, we compared the relationship between p53AIP1 or survivin gene expression and the clinicopathological status of lung cancer.

MATERIALS AND METHODS:

Forty-seven samples from non-small cell lung cancer patients were obtained between 1997 and 2003. For quantitative evaluation of RNA expression by PCR, we used Taqman PCR methods.

RESULTS:

Although no correlation between p53AIP1 or survivin gene expression and clinicopathological factors was found, the relationship between survivin gene expression and nodal status was significant (p = 0.03). Overall survival in the p53AIP1-negative group was significantly worse than in the positive group (p = 0.04); however, although survivin expression was not a prognostic factor, the combination of p53AIP1 and survivin was a significant prognostic predictor (p = 0.04). In the multivariate cox proportional hazard model, the combination was an independent predictor of overall survival (p53AIP1 (+) survivin (+), HR 0.21, 95%CI = [0.01-1.66]; p53AIP1 (+) survivin (-), HR 0.01, 95%CI = [0.002-0.28]; p53AIP1 (-) survivin (-), HR 0.01, 95%CI = [0.002-3.1], against p53AIP1 (-) survivin (+), p = 0.03).

CONCLUSION:

These data suggest that the combination of p53AIP1 and survivin gene expression may be a powerful tool to stratify subgroups with better or worse prognosis from the variable non-small cell lung cancer population.

• Authors: Shin-ichi Yamashita, Masao Chujo, Michiyo Miyawaki, Keita Tokuishi, Kentaro Anami, Satoshi Yamamoto, Katsunobu Kawahara
• Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 28 Pg. 22 (Feb 19 2009) ISSN: 1756-9966 [Electronic] England
• PMID: 19228369 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apoptosis Regulatory Proteins
• Biomarkers, Tumor
• P53AIP1 protein, human

Topics

• Adult
• Aged
• Apoptosis Regulatory Proteins (biosynthesis, genetics)
• Biomarkers, Tumor (biosynthesis, genetics)
• Carcinoma, Non-Small-Cell Lung (genetics, metabolism, pathology)
• Female
• Gene Expression
• Genes, p53
• Humans
• Lung Neoplasms (genetics, metabolism, pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Prognosis
• Survival Analysis