Abstract | BACKGROUND: METHODS: Sixty male Sprague-Dawley rats were divided into three pancreatitis groups (15 animals each) and a sham-operated group (15 animals, control group). Pancreatitis was induced by intraductal infusion of 3% taurocholate under sterile conditions. Animals were placed on one of two different antibiotic regimens (15 mg/kg ertapenem or 20 mg/kg meropenem, one shot) after the induction of pancreatitis or received no antibiotics (control). All animals were sacrificed after 24 h to study pancreatic and extrapancreatic infection. RESULTS: CONCLUSIONS:
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Authors | Fausto Catena, L Ansaloni, F Gazzotti, R Pezzilli, A Nanetti, D Santini, B Nardo, A D Pinna |
Journal | Journal of hepato-biliary-pancreatic surgery
(J Hepatobiliary Pancreat Surg)
Vol. 16
Issue 3
Pg. 328-32
( 2009)
ISSN: 1436-0691 [Electronic] Japan |
PMID | 19219398
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Thienamycins
- beta-Lactams
- Meropenem
- Ertapenem
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Topics |
- Animals
- Antibiotic Prophylaxis
- Bacterial Infections
(drug therapy, prevention & control)
- Colony Count, Microbial
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Ertapenem
- Male
- Meropenem
- Pancreatitis, Acute Necrotizing
(drug therapy, pathology, prevention & control)
- Probability
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reference Values
- Risk Factors
- Sensitivity and Specificity
- Severity of Illness Index
- Thienamycins
(pharmacology)
- beta-Lactams
(pharmacology)
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