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Restored cardiac conditions and left ventricular function after parathyroidectomy in a hemodialysis patient. Parathyroidectomy improves cardiac fatty acid metabolism assessed by 123I-BMIPP.

Abstract
A 62 year-old female hemodialysis patient underwent parathyroidectomy to treat secondary hyperparathyroidism. On the preoperative assessment, the plasma levels of parathyroid hormone (PTH) and B-type natriuretic peptide (BNP) were elevated. Echocardiography showed reduced left ventricular (LV) contraction. Myocardial iodine-123-15-(p-iodophenyl)-3-(R,S) methylpentadecanoic acid ((123)I-BMIPP) scintigraphy showed moderately reduced tracer uptake in the postero-inferior area on single-photon emission computed tomography and decreased washout on the planar images. After parathyroidectomy, the plasma levels of PTH and BNP decreased, followed by improvement in LV contraction. Myocardial (123)I-BMIPP scintigraphy revealed that the washout on planar images had increased, which suggests that myocardial (123)I-BMIPP scintigraphy is useful for estimating the effect of parathyroidectomy on cardiac function.
AuthorsMamoru Nanasato, Norihiko Goto, Satoshi Isobe, Kazumasa Unno, Haruo Hirayama, Tetsuhiko Sato, Susumu Matsuoka, Takaharu Nagasaka, Yoshihiro Tominaga, Kazuharu Uchida, Toyoaki Murohara
JournalCirculation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 73 Issue 10 Pg. 1956-60 (Oct 2009) ISSN: 1347-4820 [Electronic] Japan
PMID19179778 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biomarkers
  • Fatty Acids
  • Iodine Radioisotopes
  • Iodobenzenes
  • Parathyroid Hormone
  • Radiopharmaceuticals
  • Natriuretic Peptide, Brain
  • iodofiltic acid
Topics
  • Biomarkers (blood)
  • Echocardiography
  • Fatty Acids (metabolism)
  • Female
  • Humans
  • Hyperparathyroidism, Secondary (etiology, metabolism, surgery)
  • Iodine Radioisotopes
  • Iodobenzenes
  • Kidney Failure, Chronic (complications, metabolism, therapy)
  • Middle Aged
  • Myocardial Contraction
  • Myocardium (metabolism)
  • Natriuretic Peptide, Brain (blood)
  • Parathyroid Hormone (blood)
  • Parathyroidectomy
  • Radiopharmaceuticals
  • Recovery of Function
  • Renal Dialysis
  • Stroke Volume
  • Tomography, Emission-Computed, Single-Photon
  • Treatment Outcome
  • Ventricular Dysfunction, Left (etiology, metabolism, physiopathology, radionuclide imaging)
  • Ventricular Function, Left

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