The effect of casein phosphopeptide-amorphous calcium phosphate on erosive enamel and dentine wear by toothbrush abrasion.

Abstract

OBJECTIVE:

In addition to its role as a remineralizing agent in preventing dental caries, calcium product (CPP-ACP) delivered as a mousse (Tooth Mousse, TM) can reduce erosion of enamel and dentine. The aim of this study was to determine whether CPP-ACP could also reduce erosive tooth wear involving toothbrush abrasion.

METHODS:

Flat, polished enamel and dentine specimens (n=72) were subjected to 10 wear regimes, with each regime involving erosion in 0.3% citric acid (pH 3.2) for 10 min followed by toothbrush abrasion in a slurry of fluoride-free toothpaste and artificial saliva (1:3 ratio by weight) under a load of 2N for 200 cycles. The specimens were immersed in artificial saliva for 2h between wear regimes. In the experimental group 1, TM (containing CPP-ACP) was applied at the beginning of each wear episode for 5 min whereas TM- (without CPP-ACP) was applied in the experimental group 2. No mousse was applied in the control group.

RESULTS:

TM significantly reduced enamel wear (mean+/-S.E., 1.26+/-0.33 microm in the experimental group 1 vs 3.48+/-0.43 microm in the control group) and dentine wear (2.16+/-0.89 microm in the experimental group 1 vs 10.29+/-1.64 microm in the control group), and dentine wear was significantly less in the experimental group 1 than in the experimental group 2 (5.75+/-0.98 microm).

CONCLUSION:

The finding that TM reduced erosive tooth wear involving toothbrush abrasion, probably by remineralizing and lubricating eroded tooth surfaces, may have implications in the management of tooth wear.

• Authors: S Ranjitkar, J M Rodriguez, J A Kaidonis, L C Richards, G C Townsend, D W Bartlett
• Journal: Journal of dentistry (J Dent) Vol. 37 Issue 4 Pg. 250-4 (Apr 2009) ISSN: 1879-176X [Electronic] England
• PMID: 19157671 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Phosphates
• Caseins
• Dentifrices
• Phosphopeptides
• casein phosphopeptide-amorphous calcium phosphate nanocomplex

Topics

• Calcium Phosphates (therapeutic use)
• Caseins (therapeutic use)
• Dental Enamel (drug effects)
• Dentifrices (therapeutic use)
• Dentin (drug effects)
• Humans
• Models, Statistical
• Molar, Third
• Phosphopeptides (therapeutic use)
• Tooth Abrasion (etiology)
• Tooth Erosion (etiology, prevention & control)
• Tooth Remineralization (methods)
• Toothbrushing (adverse effects)