Elevation of plasma granzyme B levels after acute myocardial infarction.

Abstract

BACKGROUND:

Apoptosis is reported to play an important role in left ventricular (LV) remodeling after acute myocardial infarction (AMI). Granzyme B is a member of the serine esterase family, which has an important role in cellular apoptosis and extracellular matrix degradation.

METHODS AND RESULTS:

Peripheral blood samples were obtained from 33 patients with a first-onset AMI treated by percutaneous coronary intervention (mean age: 61.4+/-8.7 years old) on days 1, 7 and 14 after onset. Plasma levels of tumor necrosis factor (TNF)-alpha, a soluble form of the Fas ligand (sFasL), and granzyme B were measured. TIMI grade 3 recanalization was accomplished in all patients within 12 h after onset. The LV end-diastolic volume index (LVEDVI) was calculated on day 1 and at 6 months after onset. Plasma levels of TNF-alpha, sFasL and granzyme B increased significantly on days 7 and 14 after onset of AMI. Stepwise multivariate regression analysis showed that the plasma granzyme B level on day 14 is a significant explanatory variable for changes in the LVEDVI.

CONCLUSIONS:

Plasma levels of granzyme B increased after AMI, which might be an important factor in the progression of late LV remodeling after AMI.

• Authors: Hideyuki Kondo, Yukihiro Hojo, Rie Tsuru, Yoshioki Nishimura, Hayato Shimizu, Nozomu Takahashi, Masahiro Hirose, Tomokazu Ikemoto, Ken-Ichi Ohya, Takaaki Katsuki, Takashi Yashiro, Kazuyuki Shimada
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 73 Issue 3 Pg. 503-7 (Mar 2009) ISSN: 1346-9843 [Print] Japan
• PMID: 19145036 (Publication Type: Journal Article)

Chemical References

• FASLG protein, human
• Fas Ligand Protein
• Tumor Necrosis Factor-alpha
• Granzymes

Topics

• Adult
• Aged
• Angioplasty, Balloon, Coronary
• Apoptosis (physiology)
• Disease Progression
• Extracellular Matrix (pathology)
• Fas Ligand Protein (blood)
• Female
• Granzymes (blood)
• Humans
• Male
• Middle Aged
• Myocardial Infarction (blood, pathology, therapy)
• Predictive Value of Tests
• Regression Analysis
• Stroke Volume
• T-Lymphocytes (enzymology, immunology)
• Tumor Necrosis Factor-alpha (blood)
• Ventricular Remodeling (physiology)