Abstract |
The bacterial respiratory pathogens Bordetella pertussis and Bordetella bronchiseptica employ multiple alternative iron acquisition pathways to adapt to changes in the mammalian host environment during infection. The alcaligin, enterobactin, and heme utilization pathways are differentially expressed in response to the cognate iron source availability by a mechanism involving substrate-inducible positive regulators. As inducers, the iron sources function as chemical signals termed ferrimones. Ferrimone-sensing allows the pathogen to adapt and exploit early and late events in the infection process.
|
Authors | Timothy J Brickman, Sandra K Armstrong |
Journal | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
(Biometals)
Vol. 22
Issue 1
Pg. 33-41
(Feb 2009)
ISSN: 1572-8773 [Electronic] Netherlands |
PMID | 19130264
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
|
Chemical References |
- Bacterial Proteins
- Hydroxamic Acids
- Siderophores
- alcaligin
- Enterobactin
- Heme
- Iron
|
Topics |
- Animals
- Bacterial Proteins
(genetics, metabolism)
- Bordetella
(genetics, metabolism, pathogenicity)
- Bordetella Infections
(metabolism)
- Enterobactin
(chemistry, metabolism)
- Gene Expression Regulation, Bacterial
- Heme
(genetics, metabolism)
- Humans
- Hydroxamic Acids
(chemistry, metabolism)
- Iron
(metabolism)
- Siderophores
(chemistry, metabolism)
- Signal Transduction
(physiology)
|