Ginkgo biloba (EGB 761) affects apoptosis and nitric-oxide synthases in testicular torsion: an experimental study.

Abstract

INTRODUCTION:

We investigated the effect of ginkgo biloba on germ cell apoptosis and also on expressions of endothelial (eNOS) and inducible (iNOS) nitric oxide synthases after testicular torsion.

MATERIALS AND METHODS:

Thirty-two Wistar albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) was performed on the rats in group 1, group 2 received ginkgo biloba for a month before T/D, group 3 received only gingko biloba for a month, and group 4 was the sham group. Left testicular torsion was created in group 1 and group 2, and the testes were untwisted and replaced in the scrotum for reperfusion. No procedure was applied to group 3, and after 1 month, testes were removed in all groups.

RESULTS:

Mean apoptotic cell, eNOS, and iNOS were increased in group 1. Group 2 showed significantly decreased apoptotic cells, eNOS, and iNOS in testes compared to group 1 (P < 0.05). The rats in group 3 had significantly decreased apoptotic cell, eNOS, and iNOS values, like the sham group (P < 0.05), and this group provided basal values.

CONCLUSIONS:

Ginkgo biloba, as a free radical scavenger, seems to have a protective role against apoptosis in testicular ischemia reperfusion injury.

• Authors: Turgay Akgül, Ersagun Karagüzel, Hatice Sürer, Hatice Yağmurdur, Ali Ayyildiz, Hüseyin Ustün, Cankon Germiyanoğlu
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 41 Issue 3 Pg. 531-6 ( 2009) ISSN: 1573-2584 [Electronic] Netherlands
• PMID: 19115075 (Publication Type: Journal Article)

Chemical References

• Plant Extracts
• Ginkgo biloba extract
• Nitric Oxide Synthase

Topics

• Animals
• Apoptosis (drug effects)
• Ginkgo biloba
• Male
• Nitric Oxide Synthase (drug effects)
• Plant Extracts (pharmacology)
• Rats
• Rats, Wistar
• Spermatic Cord Torsion (enzymology, pathology)