Abstract | PURPOSE: PATIENTS AND METHODS: Medical records were examined for hemoglobin levels before and during radiotherapy, history of allogeneic blood transfusions and the time point when transfusions were given. These factors were retrospectively analyzed along with other clinical risk factors for influences on the patients' clinical outcomes. RESULTS: Thirty-two patients (26.9%) received packed red blood cell transfusion (mean, 3.4 units; range, 1-12 units) before or during radiotherapy. Median follow-up period was 39.3 months (range, 7.6-58.4 months). Patients with history of transfusion showed poorer metastasis-free survival and a trend toward poorer overall survival than non-transfused patients. When patients who received transfusions were sub-divided by the time of transfusion, those who received transfusions before radiotherapy had significantly poorer clinical outcome than those who received transfusions during radiotherapy. In a multivariable analysis, patients with pretreatment transfusion showed a higher risk of distant metastasis (HR = 3.75, 95% CI: 1.28-12.15, p = 0.017) and decreased overall survival rates (HR = 4.62, 95% CI: 1.15-18.54, p = 0.031) compared with those of other patients. CONCLUSION:
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Authors | Myong Cheol Lim, Joo-Young Kim, Tae-Hyun Kim, Sohee Park, Sun-Young Kong, Jung-Hyun Yoon, Sokbom Kang, Sang-Soo Seo, Sang Yoon Park |
Journal | Yonsei medical journal
(Yonsei Med J)
Vol. 49
Issue 6
Pg. 993-1003
(Dec 31 2008)
ISSN: 0513-5796 [Print] Korea (South) |
PMID | 19108024
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anemia
(etiology, therapy)
- Carcinoma, Squamous Cell
(complications, radiotherapy, secondary, therapy)
- Female
- Humans
- Middle Aged
- Prognosis
- Transfusion Reaction
- Treatment Outcome
- Uterine Cervical Neoplasms
(complications, radiotherapy, therapy)
- Young Adult
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