Abstract | BACKGROUND: OBJECTIVES: To characterize the regional distribution of Mn in the rat brain after subchronic exposure to Mn. This animal model holds special clinical relevance, reflecting the earlier clinical stages of manganism before chronic exposure to Mn exerts its irreversible effects. METHODS: Sprague-Dawley rats were intravenously injected with MnCl2 weekly, for a total of 14 weeks - approximately 1/10 of the lifetime of the rat. T1-weighted magnetic resonance imaging was used to detect the distribution of Mn deposition in brain tissues, as evidenced by areas of T1-weighted hyperintense signals. RESULTS: A consistent region-specific pattern of T1-weighted hyperintensities was observed in the brains of Mn-treated rats. Cortical hyperintensities were prominent in the hippocampus and dentate gyrus. Hyperintensities were also observed in the olfactory bulbs, pituitary gland, optic nerves and chiasma, pons, midbrain tegmentum, habenula, lentiform and caudate nuclei, thalamus, chorioid plexus and cerebellar hemispheres. CONCLUSIONS: Prominent Mn depositions, evidenced by T1-weighted hyperintensities in the hippocampus after subacute exposure to Mn, are compatible with the clinical picture of manganism during its early stages, and may explain its pathophysiology.
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Authors | Yoram Finkelstein, Na Zhang, Vanessa A Fitsanakis, Malcolm J Avison, John C Gore, Michael Aschner |
Journal | The Israel Medical Association journal : IMAJ
(Isr Med Assoc J)
Vol. 10
Issue 11
Pg. 793-8
(Nov 2008)
ISSN: 1565-1088 [Print] Israel |
PMID | 19070289
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Animals
- Brain
(metabolism)
- Dentate Gyrus
(metabolism)
- Hippocampus
(metabolism)
- Immunohistochemistry
- Magnetic Resonance Imaging
- Male
- Manganese
(blood, metabolism)
- Manganese Poisoning
(diagnosis, physiopathology)
- Rats
- Rats, Sprague-Dawley
- Tegmentum Mesencephali
(metabolism)
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