Intracranial hemorrhage in childhood immune thrombocytopenic purpura.

Abstract

We retrospectively analyzed 750 patients with ITP for development of intracranial hemorrhage (ICH). Seventeen cases with age range of 10 months to 18 years were studied. Ten patients were of acute ITP and seven had chronic ITP. Nine patients developed ICH one month after the onset of ITP and five patients had ICH on presentation. ICH was precipitated by trauma in four patients and possibly the use of NSAIDs in one patient. Median platelets counts at the time of ICH were 12 x 10(9)/L (range 2-50 x 10(9)/L). Most patients were treated with corticosteroids. Four patients (24%) died due to ICH.

• Authors: Dharma R Choudhary, Rahul Naithani, M Mahapatra, Rajat Kumar, Pravas Mishra, Renu Saxena
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 52 Issue 4 Pg. 529-31 (Apr 2009) ISSN: 1545-5017 [Electronic] United States
• PMID: 19058201 (Publication Type: Journal Article)
• Copyright: Copyright 2008 Wiley-Liss, Inc.

Chemical References

• Adrenal Cortex Hormones
• Anti-Inflammatory Agents, Non-Steroidal

Topics

• Adolescent
• Adrenal Cortex Hormones (therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Child
• Child, Preschool
• Craniocerebral Trauma (complications)
• Female
• Humans
• Infant
• Intracranial Hemorrhages (complications)
• Male
• Purpura, Thrombocytopenic, Idiopathic (complications, drug therapy)
• Retrospective Studies