Implanon versus medroxyprogesterone acetate: effects on pain scores in patients with symptomatic endometriosis--a pilot study.

Abstract

BACKGROUND:

Implanon has been reported to be effective in the treatment of dysmenorrhea. We compared the therapeutic efficacies of depot medroxyprogesterone acetate (DMPA) and Implanon with regard to pain relief in women with endometriosis.

STUDY DESIGN:

In a clinical research center at a university hospital, 41 patients with dysmenorrhea, nonmenstrual pelvic pain and dyspareunia associated with histologically proven endometriosis were included in an open, prospective, randomized, controlled clinical trial. Twenty-one women were assigned by computer-generated randomization to receive Implanon, and 20 women to receive DMPA. As main outcome measures of this pilot study, we evaluated pain improvement quantified according to visual analog scale score, side effects, vaginal bleeding patterns, withdrawal rate and overall degree of satisfaction.

RESULTS:

During a follow-up period of 1 year, we ascertained a clear improvement in pain intensity for both treatment options. After 6 months, the average decrease in pain was 68% in the Implanon group and 53% in the DMPA group. The side-effects profile and the overall degree of satisfaction after study termination were comparable for both treatment options.

CONCLUSION:

Concerning pain relief, the therapeutic efficacy of the contraceptive implant Implanon is not inferior to that of DMPA in symptomatic endometriosis.

• Authors: Katharina Walch, Gertrud Unfried, Johannes Huber, Christine Kurz, Michael van Trotsenburg, Elisabeth Pernicka, René Wenzl
• Journal: Contraception (Contraception) Vol. 79 Issue 1 Pg. 29-34 (Jan 2009) ISSN: 1879-0518 [Electronic] United States
• PMID: 19041438 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Contraceptive Agents, Female
• etonogestrel
• Desogestrel
• Medroxyprogesterone Acetate

Topics

• Adult
• Contraceptive Agents, Female (therapeutic use)
• Desogestrel (therapeutic use)
• Endometriosis (physiopathology)
• Female
• Follow-Up Studies
• Humans
• Medroxyprogesterone Acetate (therapeutic use)
• Middle Aged
• Palliative Care
• Pelvic Pain (drug therapy, etiology)
• Pilot Projects
• Prospective Studies
• Treatment Outcome
• Young Adult