Abstract |
Common medical conditions that require mechanical ventilation include chronic obstructive lung disease, acute lung injury, sepsis, heart failure, drug overdose, neuromuscular disorders, and surgery. Although mechanical ventilation can be a life saving measure, prolonged mechanical ventilation can also present clinical problems. Indeed, numerous well-controlled animal studies have demonstrated that prolonged mechanical ventilation results in diaphragmatic weakness due to both atrophy and contractile dysfunction. Importantly, a recent clinical investigation has confirmed that prolonged mechanical ventilation results in atrophy of the human diaphragm. This mechanical ventilation-induced diaphragmatic weakness is important because the most frequent cause of weaning difficulty is respiratory muscle failure due to inspiratory muscle weakness and/or a decline in inspiratory muscle endurance. Therefore, developing methods to protect against mechanical ventilation-induced diaphragmatic weakness is important.
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Authors | Scott K Powers, Marc DeCramer, Ghislaine Gayan-Ramirez, Sanford Levine |
Journal | Critical care (London, England)
(Crit Care)
Vol. 12
Issue 6
Pg. 191
( 2008)
ISSN: 1466-609X [Electronic] England |
PMID | 19040772
(Publication Type: Comment, Journal Article)
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Chemical References |
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Topics |
- Critical Illness
- Diaphragm
(physiopathology)
- Humans
- Muscular Atrophy
(etiology, physiopathology)
- Myofibrils
(metabolism)
- Proteins
(metabolism)
- Respiration, Artificial
(adverse effects)
- Respiratory Paralysis
(etiology, physiopathology)
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