Active and passive smoking and risk of narcolepsy in people with HLA DQB1*0602: a population-based case-control study.

Abstract

BACKGROUND:

We examined the risk of narcolepsy associated with active and passive smoking among genetically susceptible individuals.

METHODS:

We conducted a population-based case-control study in King County, Wash., USA. Between 2001 and 2005, we enrolled 67 cases through physicians and public outreach, and 95 controls through random-digit dialing. Subjects were aged between 18 and 50 years and positive for HLA DQB1*0602. All subjects were administered in-person interviews about their history of active and passive smoking.

RESULTS:

We observed an increased risk of narcolepsy associated with having lived with two or more household smokers (odds ratio, OR = 5.1; 95% confidence interval, CI: 1.6, 12.1); with a grandparent or a sibling who smoked (OR = 3.0; 95% CI: 1.1, 8.3); with a non-family household member who smoked (OR = 3.7; 95% CI: 1.6, 8.6); and with an unrelated smoker for 1-2 years (OR = 3.1; 95% CI: 1.0, 9.0). The risk of narcolepsy was not associated with exposure to smoke at work or with active smoking before age 21 or before age of narcolepsy onset.

CONCLUSION:

Passive smoking may be a risk factor for narcolepsy in subjects with HLA DQB1*0602. Future studies could help clarify whether passive smoking is an important etiologic component of narcolepsy among genetically susceptible individuals.

• Authors: Thanh G N Ton, W T Longstreth Jr, Thomas Koepsell
• Journal: Neuroepidemiology (Neuroepidemiology) Vol. 32 Issue 2 Pg. 114-21 ( 2009) ISSN: 1423-0208 [Electronic] Switzerland
• PMID: 19039244 (Publication Type: Comparative Study, Journal Article)
• Copyright: 2008 S. Karger AG, Basel.

Chemical References

• HLA-DQ Antigens
• HLA-DQ beta-Chains
• HLA-DQB1 antigen
• Membrane Glycoproteins
• Tobacco Smoke Pollution

Topics

• Adolescent
• Adult
• Case-Control Studies
• Female
• Genetic Predisposition to Disease
• HLA-DQ Antigens (genetics)
• HLA-DQ beta-Chains
• Humans
• Male
• Membrane Glycoproteins (genetics)
• Middle Aged
• Narcolepsy (epidemiology, etiology, genetics)
• Population
• Risk Factors
• Smoking (adverse effects, epidemiology, genetics)
• Tobacco Smoke Pollution (adverse effects, statistics & numerical data)
• Young Adult