[Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer].

Abstract

OBJECTIVE:

This study examined whether the two polymorphisms of GPX1 (198Pro--> Leu) and TXNRD2 (370Lys-->Arg) contributed alone or in combination, to the risk of gastric cancer development.

METHODS:

A total of 361 patients with gastric cancer and 363 cancer-free controls were recruited and their genotypes of the two polymorphisms were determined by polymerase chain reaction-based restrictive fragment length polymorphism (PCR-RFLP) method. Odds ratio (OR) and 95% confidence interval (CI) were computed using unconditional logistic regression model.

RESULTS:

GPX1 and TXNRD2 polymorphisms individually were not associated with the risk of gastric cancer. Gene-gene interaction of GPX1 and TXNRD2 polymorphisms decreased the risk of gastric cancer. Carrying the protective genotype might decrease the risk at 62% (OR = 0.38, 95% CI = 0.26-0.55, P < 0.001) as compared with the risk genotype.

CONCLUSION:

The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer.

• Authors: Jia Wang, Tong Sun, Ming Yang, Dong-Xin Lin, Wen Tan, Ke-Ji Li, Ying Xiao
• Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] (Zhonghua Yu Fang Yi Xue Za Zhi) Vol. 42 Issue 7 Pg. 511-4 (Jul 2008) ISSN: 0253-9624 [Print] China
• PMID: 19035188 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glutathione Peroxidase
• TXNRD2 protein, human
• Thioredoxin Reductase 2
• Glutathione Peroxidase GPX1
• GPX1 protein, human

Topics

• Alleles
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Glutathione Peroxidase (genetics)
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Stomach Neoplasms (genetics)
• Thioredoxin Reductase 2 (genetics)
• Glutathione Peroxidase GPX1