Immune reconstitution inflammatory syndrome manifesting as disseminated tuberculosis, deep venous thrombosis, encephalopathy and myelopathy.

Abstract

We describe an unusual case of a 25-year-old human immunodeficiency virus (HIV)-positive male with a pre-treatment CD4 count of 144 cells/microL, who had received highly active antiretroviral therapy (HAART) consisting of lamivudine, stavudine and nevirapine for three months, developing immune reconstitution inflammatory syndrome (IRIS) manifesting as disseminated tuberculosis (TB), myelopathy, encephalopathy and deep venous thrombosis (DVT). In addition to HAART and antituberculosis treatment (ATT), the patient was given non-steroidal anti-inflammatory drugs, oral vitamin B12 and heparin, which was later switched to oral warfarin.

• Authors: Mohammad Tahir, Sanjeev Sinha, S K Sharma, Ronald T Mitsuyasu
• Journal: The Indian journal of chest diseases & allied sciences (Indian J Chest Dis Allied Sci) 2008 Oct-Dec Vol. 50 Issue 4 Pg. 363-4 ISSN: 0377-9343 [Print] India
• PMID: 19035057 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Topics

• AIDS Dementia Complex (etiology)
• Acquired Immunodeficiency Syndrome (complications, drug therapy)
• Adult
• Antiretroviral Therapy, Highly Active
• Humans
• Immune Reconstitution Inflammatory Syndrome (complications, diagnosis, therapy)
• Male
• Spinal Cord Diseases (etiology)
• Tuberculosis (etiology)
• Venous Thrombosis (etiology)