Intralesional and sub-Tenon's infusion of corticosteroids for treatment of refractory periorbital and orbital capillary haemangioma.

Abstract

PURPOSE:

To evaluate the effect of combined intralesional and sub-Tenon's administration of corticosteroids for the treatment of refractory periocular and orbital capillary haemangioma in a retrospective, non-comparative study.

METHODS:

Seven infants with resistant periorbital and orbital capillary haemangioma who attended our tertiary centre from 2000 to 2005 were treated with an intralesional injection of a mixture of betamethasone 6 mg/cc and triamcinolone 10 mg/cc, by body weight, together with sub-Tenon's infusion of betamethasone 6 mg/cc and triamcinolone 40 mg/cc of a volume of 1 cc, close to the orbital lesion, in the same session. Visual axis, proptosis, pre- and post-treatment changes in four refractive parameters, and parental satisfaction were evaluated.

RESULTS:

None of the babies had proptosis or visual axis obstruction after treatment. Mean spherical power decreased by 22.7% (P=0.06). Mean spherical equivalent decreased in 34%, but the difference was not statistically significant (P=0.09). No early or late ocular side effects were observed. Mean intraocular pressure results were normal before and immediately after treatment, and during the follow-up period. Parental satisfaction score during follow-up was 9/10. Mean time to improvement was 96.43+/-58.3 days.

CONCLUSIONS:

Combined local corticosteroid administration by posterior sub-Tenon's infusion and intralesional injection in babies with extensive capillary haemangioma is associated with a satisfactory anatomical and functional outcome and there were no ophthalmic side effects.

• Authors: R Friling, R Axer-Siegel, D Ben-Amitai, N Goldenberg-Cohen, D Weinberger, M Snir
• Journal: Eye (London, England) (Eye (Lond)) Vol. 23 Issue 6 Pg. 1302-7 (Jun 2009) ISSN: 1476-5454 [Electronic] England
• PMID: 18989344 (Publication Type: Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Triamcinolone
• Betamethasone

Topics

• Adrenal Cortex Hormones (administration & dosage)
• Betamethasone (administration & dosage)
• Drug Therapy, Combination
• Female
• Hemangioma, Capillary (drug therapy)
• Humans
• Infant
• Injections, Intralesional
• Injections, Intraocular
• Intraocular Pressure
• Male
• Orbital Neoplasms (drug therapy)
• Patient Satisfaction
• Triamcinolone (administration & dosage)