Abstract | BACKGROUND: METHOD: Fifty consecutive consenting patients were randomized to receive either 1200 mg of gabapentin (Group G) or placebo (Group P) 2 h preoperatively. Preoperative anxiety was assessed on a numeric scale from 0 to 6. A SCPB was performed after a standardized induction of anesthesia. The primary outcome, analgesic drug consumption, was assessed during the procedure and postoperatively in the postanesthesia care unit and after discharge to the ward. Over the first 24 h, pain levels at rest and during swallowing were measured on a numeric scale from 0 to 10. If the pain level was more than 4/10 at rest, patients received 1 g/6 h of IV paracetamol and/or 50 mg/6 h of IV tramadol as a rescue analgesic treatment in the interval. The day before operation and 6 mo after thyroidectomy, included patients were asked to answer a neuropathic pain diagnostic questionnaire. RESULTS: Population characteristics, preoperative anxiety, intraoperative drug consumption, procedure duration, and postoperative care unit stay were comparable in both groups. Analgesic consumption during the first 24 postoperative hours was similar in both groups (G: 3 [0-5] doses/24 h; P: 3 [1-5] doses/24 h; P = NS), as well as pain at rest (G: 2,2 [0.2-3.7]; P: 2 [0-6.3]; P = NS), and during swallowing (G: 2.8 [0.4-8.9]; P: 3 [1.4-6.3]; P = NS]). Eight patients had a diagnostic questionnaire score more than 3, 6 mo after operation versus 2 in preoperative period (P = 0.04). Such delayed neuropathic pain complaints were reported in seven patients receiving SCPB alone and only in one patient receiving both SCPB and preoperative adjunctive oral gabapentin. (P = 0.01). CONCLUSION:
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Authors | Nicolas Brogly, Jean-Michel Wattier, Grégoire Andrieu, Daliana Peres, Emanuel Robin, Eric Kipnis, Laurent Arnalsteen, Béatrice Thielemans, Bruno Carnaille, François Pattou, Benoît Vallet, Gilles Lebuffe |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 107
Issue 5
Pg. 1720-5
(Nov 2008)
ISSN: 1526-7598 [Electronic] United States |
PMID | 18931238
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Amines
- Analgesics
- Cyclohexanecarboxylic Acids
- Placebos
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Adolescent
- Adult
- Aged
- Amines
(therapeutic use)
- Analgesics
(therapeutic use)
- Cyclohexanecarboxylic Acids
(therapeutic use)
- Deglutition
(physiology)
- Female
- Gabapentin
- Humans
- Male
- Middle Aged
- Nerve Block
(adverse effects)
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Placebos
- Thyroidectomy
(adverse effects, methods)
- Time Factors
- gamma-Aminobutyric Acid
(therapeutic use)
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