CD147, MMP-1, MMP-2 and MMP-9 protein expression as significant prognostic factors in human prostate cancer.

Abstract

AIM:

CD147 and MMPs have been demonstrated to be involved in tumor invasion and angiogenesis. The aim of this study was to analyze the clinicopathological significance of CD147, MMP-1, MMP-2 and MMP-9 expression in human prostate cancer (PCa) and to evaluate their involvement in the progression of PCa.

METHODS:

CD147, MMP-1, MMP-2 and MMP-9 expression was assessed in paraffin-embedded specimens collected from 62 cases of PCa and 15 cases of benign prostatic hyperplasia (BPH) by immunohistochemistry. Spearman's correlation was applied to determine possible relationships between CD147, MMP-1, MMP-2 and MMP-9 expression and PCa. The association of CD147 and MMP-2 protein expression with the clinicopathological characteristics and the prognosis of PCa was subsequently assessed.

RESULTS:

CD147was expressed in 51/62 (82.3%) PCa patients and in 2/15 (13.3%) BPH cases. MMP-1, MMP-2 and MMP-9 expression was significantly higher in PCa tissue than in BPH tissue. Using Spearman analysis, a significant positive correlation between CD147 and MMP-1, MMP-2 and MMP-9 expression was found (p <0.05). CD147 and MMP-2 expression was correlated with TMN grade and Gleason score. Patients with concurrent expression of CD147+ and MMP-2+ had the lowest survival (p <0.01).

CONCLUSION:

The results suggest that concurrent expression of CD147 and MMP may be an important characteristic of PCa which may help in the prediction of PCa progression.

• Authors: Wei-de Zhong, Zhao-dong Han, Hui-chan He, Xue-cheng Bi, Qi-shan Dai, Gang Zhu, Yong-kang Ye, Yu-xiang Liang, Wei-jun Qin, Ze Zhang, Guo-hua Zeng, Zhi-nan Chen
• Journal: Oncology (Oncology) Vol. 75 Issue 3-4 Pg. 230-6 ( 2008) ISSN: 1423-0232 [Electronic] Switzerland
• PMID: 18852494 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2008 S. Karger AG, Basel.

Chemical References

• BSG protein, human
• Biomarkers, Tumor
• Basigin
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9
• Matrix Metalloproteinase 1

Topics

• Aged
• Aged, 80 and over
• Basigin (metabolism)
• Biomarkers, Tumor
• Disease Progression
• Gene Expression Regulation, Neoplastic
• Humans
• Immunoenzyme Techniques
• Male
• Matrix Metalloproteinase 1 (metabolism)
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Middle Aged
• Neoplasm Staging
• Prognosis
• Prostate (metabolism, pathology)
• Prostatic Hyperplasia (metabolism, pathology, surgery)
• Prostatic Neoplasms (metabolism, pathology, surgery)