Abstract |
Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter variants (-31C/T and -511A/G), SMA ( hemoglobin [Hb] level <6.0 g/dL), and circulating IL-1beta levels were investigated in children with parasitemia (n= 566) from western Kenya. The IL-1beta promoter haplotype -31C/-511A (CA) was associated with increased risk of SMA (Hb level <6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P < .05) and reduced circulating IL-1beta levels (p <.05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA (OR, 0.52 [95% CI, 0.18-1.16]; p =.11) and elevated IL-1beta production ( p<.05). Compared with the non-SMA group, children with SMA had significantly lower IL-1beta levels and nonsignificant elevations in both IL-1 receptor antagonist (IL-1Ra) and the ratio of IL-1Ra to IL-1beta. The results presented demonstrate that variation in IL-1beta promoter conditions susceptibility to SMA and functional changes in circulating IL-1beta levels.
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Authors | Collins Ouma, Gregory C Davenport, Gordon A Awandare, Christopher C Keller, Tom Were, Michael F Otieno, John M Vulule, Jeremy Martinson, John M Ong'echa, Robert E Ferrell, Douglas J Perkins |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 198
Issue 8
Pg. 1219-26
(Oct 15 2008)
ISSN: 0022-1899 [Print] United States |
PMID | 18781863
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Anemia
(genetics, immunology, physiopathology)
- Animals
- Child, Preschool
- Female
- Genotype
- Haplotypes
- Humans
- Infant
- Interleukin-1beta
(biosynthesis, blood, genetics)
- Malaria, Falciparum
(complications, genetics, immunology, parasitology)
- Male
- Parasitemia
(complications, genetics, immunology, parasitology)
- Plasmodium falciparum
- Polymorphism, Genetic
- Promoter Regions, Genetic
(genetics)
- Severity of Illness Index
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