The role of hepatitis B virus x gene in development of primary hepatocellular carcinoma.

Abstract

Primary hepatocellular carcinoma (HCC) is one of the most common cancers occurring in human, and there is strong epidemiological evidence suggesting that persistent hepatitis B virus (HBV) infection is the most important risk factor for its development.HBx gene was found to be a transactivator recently. Its continuous expression in hepatocytes may transactivate cellular genes which can play a certain role in development of HCC. TheHBx gene fragment was used to construct a recombinant eukaryotic expression vector pCEP4 and introduced into HepG2 cells. The effect ofHBx gene on HCC cells growth and its molecular mechanism in HCC cells regulation were investigated.

• Authors: X Tao, D Shen, H Ren, X Zhang, D Zhang, B Gu, J Ye
• Journal: Science in China. Series C, Life sciences (Sci China C Life Sci) Vol. 43 Issue 3 Pg. 293-301 (Jun 2000) ISSN: 1006-9305 [Print] China
• PMID: 18726385 (Publication Type: Journal Article)