[Histone specific proteinase and DNase activity of spleen lymphocyte nuclei during oncogenesis and under the effect of hydrobromide-5-(5',6' benzocoumaroyl-3')-methylaminouracil].

Abstract

The features of histone proteolysis, their carbonylation level and endonucleolysis intensity were studied in the spleen lymphocytes of rats with transplanted Guerin's carcinoma and under the conditions of hydrobromide-5-(5',6' benzocoumaroyl-3')-methylaminouracil (BCU) action. The intensification of oxidizing histone destruction and histone-specific protease activity during oncogenesis and under conditions of BCU action was shown. DNase I and DNase II enzymatic activities of spleen lymphocytes of rats with tumour were decreased on different stages of tumour development, however, they were increased under conditions of chemical compound administration.

• Authors: H P Kopyl'chuk, M M Marchenko, H V Iakovyshyn
• Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) (Ukr Biokhim Zh (1999)) 2008 Jan-Feb Vol. 80 Issue 1 Pg. 40-5 Ukraine
• PMID: 18710025 (Publication Type: English Abstract, Journal Article)

Chemical References

• 5-(5',6'-benzocoumarin-3')-methylaminouracil hydrobromide
• Antineoplastic Agents
• Uracil
• Deoxyribonucleases
• Endopeptidases
• histone proteases

Topics

• Animals
• Antineoplastic Agents (administration & dosage, pharmacology, therapeutic use)
• Cell Nucleus (drug effects, enzymology)
• Deoxyribonucleases (metabolism)
• Endopeptidases (metabolism)
• Female
• Lymphocytes (cytology, drug effects, enzymology)
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy, enzymology, pathology)
• Rats
• Spleen (cytology, drug effects, enzymology)
• Uracil (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)